STKE: Looking After Polysialic Acid

CMP substitutions preferentially inhibit polysialic acid synthesis.

It is widely reported that derivatives of sugar moieties can be used to metabolically label cell surface carbohydrates or inhibit a particular glycosylation. However, few studies address the effect of substitution of the cytidylmonophosphate (CMP) portion on sialyltransferase activities. Here we first synthesized 2'-O-methyl CMP and 5-methyl CMP and then asked if these CMP derivatives are recog...

Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice.

alpha2,8 Polysialic acid (PSA) is a carbohydrate attached to the glycoprotein backbone of the neural cell adhesion molecule (NCAM) and implicated in nervous system development and repair. Here, we investigated whether PSA can improve functional recovery after peripheral nerve lesion in adult mice. We applied a functional PSA mimicking peptide or a control peptide in a polyethylene cuff used to ...

Diversity in sialic and polysialic acid residues and related enzymes*

The occurrence of extensive diversity in the family of sialic acids is now well recognized but biological signi®cance of this diversity has been clari®ed only partially. In 1986 we showed natural occurrence of deaminated form of neuraminic acid, 2-keto-3-deoxy-Dglycero-D-galacto-nononic acid (KDN) as a capping residue of polysialyl chain of rainbow trout egg polysialoglycoprotein. Subsequent st...

Polysialic Acid-N-Trimethyl Chitosan Nanoparticles for Oligonucleotide Delivery

296 ©2013 Society For Biomaterials

-8 polysialic acid for immuno-targeting tumor cells*